Faster Cross-Bridge Relaxation Rates Correlate with Increased Tension Cost in Hcm with the R403Q Myh7 Mutation
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چکیده
منابع مشابه
Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation.
The first mutation associated with hypertrophic cardiomyopathy (HCM) is the R403Q mutation in the gene encoding β-myosin heavy chain (β-MyHC). R403Q locates in the globular head of myosin (S1), responsible for interaction with actin, and thus motor function of myosin. Increased cross-bridge relaxation kinetics caused by the R403Q mutation might underlie increased energetic cost of tension gener...
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A novel homozygous mutation in the TNNT2 gene encoding cardiac troponin T (cTnT K280N) was identified in one hypertrophic cardiomyopathy (HCM) patient undergoing cardiac transplantation. Mass spectrometry, protein and mRNA analyses revealed expression of the mutant alleles without evidence of haploinsufficiency. Kinetics of contraction and relaxation of myofibrils from a frozen left ventricular...
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Increased transcription rates correlate with increased reversion rates in leuB and argH Escherichia coli auxotrophs.
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2014
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.3117